The core activity of Arcoscreen SA is the development and application of an innovative technology for GPCR primary cell screening, to support pharmaceutical companies in identifying promising G-protein-coupled receptor (GPCR) compounds in primary cells. This includes providing services such as identifying the mechanism of action of drugs in primary cells, activating GPCRs, and developing stable cell lines.
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Gα activation
Identification of the molecular mode of action in primary cells, including determination of the implicated Gα subunits, EC50 and IC50 values, 384-well microfluidic plate format.
GTPγS activation
Activation of GPCRs in primary or mammalian cells, including determination of dose-response curves, EC50 and IC50 values, 384-well microfluidic plate format.
Arcoflow platform
Primary cell screening platform combining a biological assay and a microfluidic device to identify the molecular mode of action of compounds.
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