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Pharvaris GmbH

Summary

About the company

Pharvaris GmbH is a late‑stage biopharmaceutical company developing novel oral bradykinin B2‑receptor antagonists. The company focuses on bradykinin‑mediated diseases, including hereditary angioedema (HAE) and acquired angioedema due to C1‑inhibitor deficiency, and is developing deucrictibant in immediate‑release and extended‑release formulations for on‑demand and prophylactic treatment.

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Development of oral therapies for bradykinin-mediated angioedema

Development of investigational oral therapies based on bradykinin B2 receptor antagonists for bradykinin-mediated angioedema, in particular hereditary angioedema and AAE-C1INH.

Clinical development of Deucrictibant

Investigational orally administered bradykinin B2 receptor antagonist in clinical development for prevention and acute treatment of HAE and AE-BK attacks.

Prevention of HAE attacks

Once-daily oral extended-release tablet with Deucrictibant for prevention of HAE attacks; therapeutic exposure over 24 hours and Phase 3 development.

On-demand treatment of HAE attacks

Oral immediate-release capsule with Deucrictibant for the rapid treatment of HAE attacks; therapeutic exposure within 15–20 minutes and Phase 3 development.

Development of therapies for AAE-C1INH

Development of treatment approaches for acquired angioedema due to C1-INH deficiency as a bradykinin-mediated disease within the clinical pipeline.

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Pharvaris GmbH

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