The core activity of Spirochrome is the development and manufacture of fluorescent probes and reagents for live-cell fluorescence microscopy. These products enable researchers to examine living cells with minimal disturbance, thereby preserving the biological integrity of the cells. The company focuses on producing high-quality, photostable and cell-permeable fluorophores specifically designed for the demands of live-cell imaging.
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Live-cell fluorescence probes for DNA, actin, microtubules, Golgi, peroxisomes, lysosomes, mitochondria, plasma membrane and other target structures; fluorogenic, cell-permeable and for live-cell imaging.
HaloTag and SNAP-Tag ligands
Chloroalkane and benzylguanine ligands for HaloTag and SNAP-Tag labeling in cellular fluorescence experiments; available in multiple colours for live- and fixed-cell imaging.
Membrane voltage probes
Fluorescent reporters for plasma membrane and organelle membrane voltage, including Flipper-TR, Halo-Flipper, as well as ER-, Mito- and Lyso-Flipper variants.
Mitochondria and plasma membrane probes (PKmito & PKmem)
Fluorescence probes for live- and fixed-cell imaging of mitochondria and plasma membrane; low phototoxicity, high photostability and variants for different channels.
Actin imaging probes
Fluorescent actin probes for live-cell imaging and fast actin dynamics, including SPY-, SiR- and FastAct variants as well as the Actin_TestKit for multiple applications.
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