Veraxa Biotech Holding AG develops antibody-based cancer therapeutics, including antibody–drug conjugates (ADCs) and BiTAC bispecific formats, and employs proprietary technologies such as droplet‑based functional antibody screening, genetic code expansion for positional conjugation, and bioorthogonal click chemistry. The company is advancing a proprietary oncology pipeline that includes ADC and BiTAC TCE programs, with the VX‑A901 program in clinical studies for AML.
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Bi-targeted T-cell-engaging bispecific molecules with two complementary antibody precursors; CD3 binding is activated only upon co-localisation on tumour cells to reduce off-tumour toxicity.
ADC technologies
Antibody-drug-conjugate technologies with genetically precise conjugation-site positioning, efficient click chemistry and proprietary payloads for homogeneous, stable ADCs with improved pharmacokinetics.
Functional antibody screening
High-throughput droplet microfluidics with single-cell analysis to identify functional antibodies against various targets, including internalising as well as agonistic and antagonistic antibodies.
BiTAC platform
Antibody platform with two complementary precursors that only form the therapeutically active molecule upon simultaneous target binding on cancer cells, enabling selective activation.
Pipeline of novel antibody-based cancer therapeutics
Development of a clinical pipeline of novel oncology programmes, in particular BiTAC-TCEs, BsADCs, BiTAC-ADCs and monoclonal antibodies for AML, breast, lung, colon and pancreatic cancer.