The core activity of Ymmunobio is the development of preclinical cancer therapeutics, particularly antibodies that influence the immune system and directly inhibit cancer cells. The company focuses on developing innovative treatments for cancer patients, especially for solid tumors, and has already made progress in developing antibodies that reactivate the immune system and directly inhibit cancer cells.
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Antibody-based therapies for solid tumors, focusing on first-in-class programmes against NPTXR and on hard-to-treat tumour types.
Antibody-Drug-Conjugates (ADC)
Dual-payload anti-NPTXR ADCs with a 4+4 linker–payload architecture, designed for precise tumour targeting and cytotoxic payload delivery; programme YB-811 in the preclinical stage.
Radiopharmaceuticals (RPT)
NPTXR-targeted radiopharmaceuticals for imaging and therapy with 177Lu and 161Tb, including RPT-Dx and RPT-Tx; programmes YB-830, YB-831 and YB-832.
Bi-specific T-cell engagers (BiTCE)
Bi-specific T-cell engagers that redirect T cells to NPTXR-positive tumours and enable selective immune-mediated tumour cell killing; programmes YB-820 and YB-821.
Tri-specific T-cell engagers (TriTCE)
Tri-specific T-cell engagers with an aCD3 and aCD28 component for T-cell activation against NPTXR-positive tumours; programme YB-880 in the lead-optimization stage.